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Fragmin 1. 2,5. 00 IU0.Summary of Product Characteristics SPC.Fragmin 1. 2,5. 00 IU0.Difference Between Summary Trial And Summary Judgement Rule' title='Difference Between Summary Trial And Summary Judgement Rule' />Fragmin 1.IU single dose syringe containing dalteparin sodium 1.IU anti Factor Xa in 0.IUml. For excipients see section 6.Fragmin does not contain preservatives.Potency is described in International anti Factor Xa units IU of the 1st International Standard for Low Molecular Weight Heparin.Treatment of venous thromboembolism VTE presenting clinically as deep vein thrombosis DVT, pulmonary embolism PE or both.Patients with solid tumours Extended treatment of symptomatic venous thromboembolism VTE and prevention of its recurrence.Treatment of venous thromboembolism VTE presenting clinically as deep vein thrombosis DVT, pulmonary embolism PE or both Adults.A single dose of Fragmin is administered subcutaneously, once daily according to the following weight ranges.Monitoring of the anticoagulant effect is not usually necessary.Weight kgDose. 46 5.IU. 1. 2,5. 00 IU.IU. 8. 3 and over.Get the latest news and analysis in the stock market today, including national and world stock market news, business news, financial news and more.IU. Abbreviations IU International Unit.The single daily dose should not exceed 1.IU. Simultaneous anti coagulation with vitamin K antagonists can be started immediately.Treatment with Fragmin is continued until the prothrombin complex levels Factor II, VII, IX and X have decreased to a therapeutic level.At least five days of combined treatment is normally required.Patients with solid tumours Extended treatment of symptomatic venous thromboembolism VTE and prevention of its recurrence.Month 1 Administer Fragmin 2.IUkg total body weight subcutaneously SC once daily for the first 3.The total daily dose should not exceed 1.IU daily. Body Weight kgDose IUlt 4.Maximum dose of 1.IU was used in patient weighing up to 1.CLOT study. In the case of chemotherapy induced thrombocytopenia, Fragmin dose should be adopted as follows In patients receiving Fragmin who experience platelet counts between 5.Fragmin should be reduced by 2,5.IU until the platelet count recovers to 1.In patients receiving Fragmin who experience platelet counts lt 5.Fragmin should be discontinued until the platelet count recovers above 5.Months 2 6. Fragmin should be administered at a dose of approximately 1.IUkg, subcutaneously, once daily using fixed dose syringes and the table shown below.Body Weight kgDose IU5.Learn the definition of fare and fair with example sentences and quizzes at Writing Explained.Summary Judgment. Displaying Modal And Modeless Windows Forms Flow . A procedural device used during civil litigation to promptly and expeditiously dispose of a case without a trial.It is used when there is no.Fragmin 12,500 IU0.Summary of Product Characteristics SPC by Pfizer Limited.Recommended duration of treatment is 6 months first month of Fragmin treatment is included.Relevance of continuing treatment beyond this period will be evaluated according to individual riskbenefit ratio, taking into account particularly the progression of cancer.No data is available with dalteparin beyond 6 months of treatment in the CLOT study.In the case of chemotherapy induced thrombocytopenia, Fragmin dose should be adopted as follows With platelet counts lt 5.Difference Between Summary Trial And Summary Judgement Rule' title='Difference Between Summary Trial And Summary Judgement Rule' />Fragmin dosing should be interrupted until the platelet count recovers above 5.For platelet counts between 5.Fragmin should be reduced as illustrated in the table below depending on the patients weight.Once the platelet count has recovered to 1.Fragmin should be re instituted at full dose.Body WeightkgScheduled Fragmin Dose IUReduced Fragmin Dose IU5.Renal failure In the case of significant renal failure, defined as a creatinine clearance lt 3.Fragmin should be adjusted based on anti Factor Xa activity.If the anti Factor Xa level is below or above the desired range, the dose of Fragmin should be increased or reduced respectively, and the anti Factor Xa measurement should be repeated after 3 4 new doses.This dose adjustment should be repeated until the desired anti Factor Xa level is achieved.As an indication, on the basis of the data available in CLOT, the observed mean levels min, max between 4 and 6 hours after administration in patients without severe renal insufficiency were 1.IU anti Factor Xaml 0.IU anti Factor Xaml 0.IUkg OD. Anti Factor Xa activity determinations were conducted by the chromogenic method.For patients with an increased risk of bleeding, it is recommended that Fragmin be administered according to the twice daily regimen detailed in the Summary of Product Characteristics for Fragmin 1.IU1ml ampoules or Fragmin Multidose Vial.Paediatric population.The safety and efficacy of dalteparin sodium in children has not been established.Currently available data are described in sections 5.Monitoring Anti Xa levels in children.Measurement of peak anti Xa levels at about 4 hours post dose should be considered for certain special populations receiving Fragmin, such as children.For therapeutic treatment with doses administered once daily, peak anti Xa levels should generally be maintained between 0.IUm. L measured at 4 hours post dose.In the case of low and changing physiologic renal function such as in neonates, close monitoring of anti Xa levels is warranted.For prophylaxis treatment the anti Xa levels should generally be maintained between 0.IUm. L. As with all antithrombotic agents, there is a risk of systemic bleeding with Fragmin administration.Care should be taken with Fragmin use in high dose treatment of newly operated patients.After treatment is initiated patients should be carefully monitored for bleeding complications.This may be done by regular physical examination of the patients, close observation of the surgical drain and periodic measurements of hemoglobin, and anti Xa determinations.Elderly. Fragmin has been used safely in elderly patients without the need for dosage adjustment.Method of administration.By subcutaneous injection, preferably into the abdominal subcutaneous tissue anterolaterally or posterolaterally, or into the lateral part of the thigh.Patients should be supine and the total length of the needle should be introduced vertically, not at an angle, into the thick part of a skin fold, produced by squeezing the skin between thumb and forefinger the skin fold should be held throughout the injection.Known hypersensitivity to Fragmin or other low molecular weight heparins andor heparins e.II acute gastroduodenal ulcer cerebral haemorrhage known haemorrhagic diathesis or other active haemorrhage serious coagulation disorder acute or sub acute septic endocarditis haemorrhagic pericardial effusion and haemorrhagic pleural effusion injuries to and operations on the central nervous system, eyes and ears.In patients receiving Fragmin for treatment rather than prophylaxis, local andor regional anaesthesia in elective surgical procedures is contra indicated with high doses of dalteparin such as those needed to treat acute deep vein thrombosis, pulmonary embolism, and unstable coronary artery disease.In cancer patients with body weight lt 4.Fragmin should not be used for extended treatment of symptomatic VTE and prevention of its recurrences due to lack of data.Dalteparin should not be used in patients who have suffered a recent within 3 months stroke Unless due to systemic emboli.Do not administer by the intramuscular route.Due to the risk of haematoma, intramuscular injection of other medical preparations should be avoided when the twenty four hour dose of dalteparin exceeds 5,0.IU. Caution should be exercised in patients in whom there is an increased risk of bleeding complications, e.Interactions Section.Caution shall also be observed at high dose treatment with dalteparin such as those needed to treat acute deep vein thrombosis, pulmonary embolism, and unstable coronary artery disease.Limited data are available regarding the safety and efficacy of antithrombotic therapy in patients with primary or metastatic tumours of the brain who develop concurrent thromboembolic events.There is a risk of fatal intracranial bleeding with use of anticoagulation in this category of patients.Therefore, if the treatment with Fragmin was considered, it should be monitored closely with regular re assessment of the status of tumour involvement of the brain and other individual risks.Thrombocytopenia, should it occur, usually appears within three weeks following the beginning of therapy.Therefore, it is recommended that the platelet counts are measured before starting treatment with Fragmin and monitored closely in first three weeks and regularly thereafter during the treatment.Special caution is necessary in rapidly developing thrombocytopenia and severe thrombocytopenia lt 1.Fragmin or other low molecular weight mass heparins andor heparin. Issuu is a digital publishing platform that makes it simple to publish magazines, catalogs, newspapers, books, and more online. Easily share your publications and get. News of Sun City Center January 2. NOKP Media. News of Sun City Center January 2. Published on Dec 2. Sun City Center, Florida. Kings Point, Florida. Tlchargez et jouez gratuitement des jeux de destruction de billes en franais. Dcouvrez plus de 1000 jeux PC tels que Luxor. How to Change Your Voice to Sound More Confident.We all know that being seen as confident, but not cocky, at work can have a positive effect on our careers.From one on one meeting with your boss to giving a presentation to the whole team, your voice is one of the most important parts of project confidence.Heres how to adjust your voice so that how you say something has as much impact as what you say Evaluate Areas to Work On.You may not need to work on all of the following issues, but thinking about each area and how you measure up gives you concrete things to work on.If you have trouble evaluating your own voice or way of speaking, ask a friend or trusted colleague to help, or record yourself speaking to get a more objective sense of your own habits.Tone The way you say something often has an impact on what people actually hear.Two of the most common examples are vocal fry heres a video example from the BBC and up speak, or using a higher pitch at the end of sentences similar to the tone used when asking a question.Not coincidentally, both of these traits that are thought to undermine credibility are commonly associated with female voices.Speaking Cadence If you speak very quickly or without many pauses, it can come across as nervousness.Try these exercises to help you have more deliberate articulation.Volume Speaking too softly or too loudly does not project confidence.You want to aim for a volume slightly above your normal speaking level so that youre clearly heard without coming off as abrasive.Filler words Um, ah, and like are all common filler words that keep what youre saying from flowing smoothly.Try these exercises from a professional public speaking coach to cut down on your own filler words.Vocal tics The area you may need the most help from a friend in analyzing is common phrases or vocal tics you have.Maybe you use the same phrase when youre buying time to think, like, Thats a great question.Or you could be undermining yourself with phrases like, Sorry to interrupt.Im not sure if this matters, but.Toastmasters has a great PDF guide and Six Minutes lays out breathing and vocal exercises you can do to generally improve your vocal presence.For example, to work on your resonance Raise your volume a bit and say Mmmmmmmmy name is Repeat this ten times up and down your vocal range.Once you know where you need to improve, get to work building new habits by practicing as much as possible.Practice New Habits.Changing the way you speak is difficult, but the more you practice, the easier it will be for you to build new habits.New album. includes safe sound randy and alakazam a joyous record dazed assured, accomplished and confident 810 mixmag.After a while, projecting confidence should become second nature.Since you might not have presentations or other opportunities to practice often, here are some other situations where you can test out your new techniques Chatting with colleagues While you dont necessarily need to project a ton of confidence around the water cooler, small talk with coworkers gives you a low stakes situation in which to practice.Sharing your ideas during meetings Having your ideas heard and respected can be influenced by how confident you sound while laying them out.Even if you make off with an ATM, it can be incredibly hard to crack them open.But given the brute force already demonstrated by these criminals, something tells me.Nuclear Coffee Recover Keys 9.Enterprise and CMD USB Version Final Used to scan, search and find serial numbers and activation codes of programs.Next time you share an idea, focus on at least one of the areas you want to improve.Giving feedback When giving feedback about someone elses work or skills, make a conscious effort to practice for at least one of the areas you want to improve on.Eventually, you want to get to the point where your confident tone positively impacts how seriously your feedback is taken.Asking questions Whether at a meeting, during a training, or at a networking event, this is a very quick way to practice your vocal confidence.I love explaining things to small groups of people and through writing on the web, but when itRead more Read.Consider Other Confidence Boosters.Beyond your voice, you can work on other things to present yourself as confident and come across better at work.Take up space Stand with your feet hip or shoulder width apart, keep your spine straight but not frozen, youre not a robot, and try to use arm and hand gestures as you naturally would when talking.Improve eye contact When speaking to a group, make eye contact with different people in the audience for about 3 5 seconds each.In a one on one situation, its okay to glance away and then make eye contact again if you feel things getting awkward.Use open body language Dont cross your arms, stuff your hands into your pockets, or cross your legs.Keeping your body relaxed and open makes you look at ease and confident.Its not easy to change your behavior, including the way you speak, so be patient with yourself and try to put into practice your new habits as frequently as you can.Sound-Forge-Pro-11-Full-Crack-Serial-Key-Free-Download.png' alt='Sound Forge 10 Pro Crack Serial Codes' title='Sound Forge 10 Pro Crack Serial Codes' />How to Be a Polite Pot Tourist.Last weekend I purchased some marijuana.Not from some friend of a friend of a friend, but from an actual dispensary in Boulder, Colorado.Boulder, like the rest of Colorado, has recreational marijuana dispensaries where you can purchase weed legally.It was cool. But while my partner had purchased legal marijuana in the past, I didnt know the first thing about the standard operating procedure of bud buying.If youre not a native, or are visiting a state just to get some cannabis while you vacation, you might want to adhere to a few easy to follow guidelines to make yourself a model dispensary customer.The dispensary, as well as the locals, will appreciate it.Keep Your ID Handy.Visiting a dispensary involves proving youre 2.ID. Youll have to show it twice first when you walk in the door, and again when youre finally purchasing your recreational cannabis.Dispensaries are rigorous in their ID checks, with some scanning the IDs to ensure theyre legitimate.When you picture someone smoking weed, a person cranking out reps in the gym is probably the lastRead more Read.Bring Cash Dont count on using your bank card for purchases at a dispensary.Since marijuana is still considered a Schedule I narcotic on a federal level, its illegal for dispensaries to use bank accounts to process transactions, and that means you arent able to purchase it with your debit or credit card.Youll need cash in most situations.Some dispensaries have ATMs inside for your convenience, but you should call ahead to double check.Plan Ahead. You should be prepared before you walk in the door and familiar with what you might be interested in purchasing.That means doing a little research beforehand, checking out the dispensarys site and inventory, and asking friends more familiar with marijuana than you about the best way to get started if its your first time.Be sure to check their hours as well some dispensaries are open late, some open early, and some are closed on certain days of the week.Cameras and Phones are a No No.You should shy away from last minute lookups and sharing with the world your current weed friendly situation until youre home.I was nearly ejected from the first dispensary I visited simply because my DSLR was hanging off my wrist, despite it having a lens cap.Dispensaries have a pretty strict no photos policy that you should adhere to unless you want to get kicked out of the store. Best Colleges For Software Engineering In Kerala Na on this page. Be Nice to Your Bud Tender.Your bud tender is your marijuana middleman, the person behind the counter that helps you pick the right product.That means you should treat them with the same respect youd show your friendly neighborhood mixologist, and not like some stoner who just loves weed.Theyre happy to help as long as youre polite.It helps to think about your questions beforehand, so youre not staring dumbfounded while your bud tender waits for your brain to catch up to your mouth.Marijuana has a healthier image than many other drugs or, depending on who you ask, alcohol, andRead more Read.You shouldnt feel obligated, but if youd like to tip your bud tender, you should check the rules beforehand.Some states, like Washington, allow tipping as long as it isnt linked to product pricing or used to avoid paying certain taxes.Smoke Em if You Got Em at HomeSmoking marijuana in public is still illegal, despite the growing number of states legalizing recreational use.That means you cant smoke it outside the dispensary you just walked out of.Some states, like Maine and Massachusetts, will fine offenders up to 1. 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Av Voice Changer Software Diamond . Update My Garmin Streetpilot C530 Price here. La Paz is the administrative capital of Bolivia, while Sucre is the constitutional capital and the seat of the Supreme Court. La Paz was established in 1548, and is. I really like beer. No, I really like beer. That means Im constantly on the hunt for beers I cant get in my current hometown of San Francisco and broker deals. The Texarkana Gazette is the premier source for local news and sports in Texarkana and the surrounding Arklatex areas. Should men be fighting to protect Western women in the wake of the Muslim rape attacks in Cologne. In this guest post, Kyle from This is Trouble says no. Jalopnik. This is the 1. Laurel Twincam 2. V Turbo Medalist CLUB L, which means its a top of the line C3. Laurel, and Im fairly sure it also means that it has Nissans RB2. DET engine, a twin cam, two liter turbo straight six. More midsize executive cars need two liter inline sixes. La Paz Wikitravel. La Paz. For other places with the same name, see La Paz disambiguationLa Paz is the administrative capital of Bolivia, while Sucre is the constitutional capital and the seat of the Supreme Court. La Paz was established in 1. Andes. Altitude of the city ranges from about 4,0. El Alto where the airport is located to 3,1. It is the highest national capital in the world. The sight from the air as one flies into La Paz is incredible. First, one sees the sprawling shantytowns of El Alto, slowly giving way to the sight of La Paz itself, clinging tenuously to the sides of what looks like a large gash in the earth. Bolivian Palace of Government in La Paz. UnderstandeditCity view with Illimani at 6. OrientationeditLa Paz was built in a canyon created by the Choqueyapu River now mostly built over, which runs northwest to southeast. The citys main thoroughfare, which roughly follows the river, changes names over its length, but the central tree lined section running through the downtown core is called the Prado. La Paz geography, in particular the altitude, reflects the citys society the lower you go, the more affluent. While many middle class paceos live in high rise condos near the center, the really rich houses are located in the lower neighborhoods southwest of the Prado. The reason for this division is that the lower you go in the city the milder the weather is. And looking up from the center, the surrounding hills are plastered with makeshift brick houses of those struggling in the hope of one day reaching the bottom. The satellite city of El Alto, in which the airport is located, is spread over a broad area to the west of the canyon, on the altiplano. By planeeditEl Alto International Airport IATA LPB ICAO SLLP, El Alto. This is the worlds highest international airport at 1. There is an airport departure tax of US2. Bs. 17. 4 for international flights, Bs. Tax can only be paid in cash, but several ATMs which also give out US are available at the airport. Tax not applicable for Bo. A national flights March 2. Most South American airlines LAN, TACA, Avianca, Sky. Airline etc. serve El Alto Airport as well local airlines Boliviana de Aviacin Bo. A, Transporte Areo Militar TAM, Aerocon and Amaszonas. Most international flights will make a stop over in Santa Cruz to pick up or drop off passengers, and load up fuel planes depart La Paz as light as possible, and early in the morning when air is denser. American Airlines is currently the only U. S. carrier serving Bolivia, with one daily flight from Miami. State funded Bo. A and TAM usually for a cheaper price serve major domestic destinations as well as some major South American hubs. Aerocon mainly provides air links to communities in the Beni Department via their hub Trinidad. Amaszonas provides direct service to tourist destinations like Rurrenabaque or Uyuni. LAB Lloyd Areo Boliviano was Bolivias national airline until April 2. Bolivian government due to financial problems. Another private operator, Aerosur, has also now ceased operations, due to a dispute with the Government over unpaid taxes. While you may be in the practice of racing to immigration when you get off a plane, in order to avoid long queues, forget about this in La Paz. Take things very easily or you will be seriously out of breath and may suffer medical complications. Just walk slowly to the immigration area. From the airport, the official rate for a taxi into central La Paz is Bs 7. US1. 0. Only use radio taxis with a sign on the roof. Shared vans cost Bs 3. US0. 5. 0. When returning to the airport, please give yourself plenty of time if taking the bus. Often they are full once they pass near Plaza San Francisco, especially during rush hour 5 7. PM. The first bus leaves from Plaza Isabel de Catlica in Sopocachi at 6. As of 2. 01. 5 a company called South West Tours offers a premium to and from airport transfer for U 5. US bound flights take off and arrive. If you are taking a TAM flight OUT of La Paz airport be VERY careful to verify which airport it is leaving from, some TAM flights leave from the El Alto Intl airport and others from the military base airport. As of Nov. 2. 01. TAM flights seem to be leaving from El Alto Intl. May 2. 01. 2 update TAM flights do sometimes still leave from the military airport by August 0. TAM had ceased operations due to failing regulatory requirements please editremove this when situation changes. The main bus terminal is in Central Park, near the upper end of the Prado Google Map and a 1. Note that buses arriving from Lake Titicaca the route for entering overland from Puno, Peru and Sorata terminate at a plaza near the city cemetery Cementerio farther to the west. Buses from Quime terminate in the El Alto bus terminal. There is no need to buy tickets upfront in one of the many travel agencies, if possible. Some agencies charge insane markups 5. And they are also not honest about the service they are selling. Its better to show up a few hours before the scheduled departure at the terminal and buy tickets there. Buses leaving La Paz usually stop in El Alto to pick up more passengers. It sometimes takes one or two hours until you really leave the city. Another option to go from La Paz to Cusco, Copacabana or Puno to take one of the Bolivia Hop buses. This service allows you to hop on or hop off at any of these places. They also provide border assistance in Spanish and English and do not make unauthorized stops. Bolivia hop is a new company and appears to be well ran and very safe. Cochabamba 7 8 hr. Normal day buses cost around Bs 2. Bolivar cost Bs 9. Semi cama between the two. Oruro 3 hr, Bs 1. To Chile, buses run to Arica, around 8 hr, some continuing to Iquique 1. AM, later buses will result in arriving in Iquique in the middle of the night. By bicycleeditHundreds of people cycle around Bolivia each year and most of them pass through La Paz. If you are one of those, read on. If you are not and you want to be free, get a bicycle and read on. If you are getting into La Paz from the north Titicaca, Per, west Chile, Tiwanaku, south Oruro, Sajama etc., you will have to pass through El Alto best avoided after dark and then you will have to take the plunge down to the centre of La Paz. Traffic in El Alto and La Paz is chaotic and pollution makes cycling more difficult. To get down to La Paz, it is probably best to follow the autopista highway, as it has a broad shoulder on both sides watch out for the holes. Traffic on the autopista can be heavy, but the shoulder is rarely used, except by the public transportation. Many other routes are possible, but some streets can be extremely steep. Check your brakes If you are coming from the yungas Coroico, you will get in through Avenida de las Americas. There is an excellent Casa de Ciclistas 2. La Paz. Get aroundeditColonial buildings on Calle Jaen. There are three types of shared public transportation in La Paz regular buses or micros shared vans, called mini buses, and shared taxis running set routes advertised on the windshield, called trufis. The former cost Bs 1,3. Bs 1,5. 0 2,3. 0 depending on duration. A trufi will generally cost you Bs 3 3. All types have their routes indicated on the windshield, but mini buses have the bonus of fare collectors hanging out the side, yelling out routes in a rapid, auctioneer like manner. You can hail a bus or mini bus anywhere to get off, just yell out voy a bajarBy taxieditThe easiest way to get around is by taxi. They arent metered, so agree on a fare before boarding a ride within downtown should be about Bs 6 8. If you want to go further, ask two or more taxi drivers before boarding. A normal ride by taxi from downtown to a place within the city wont cost more than Bs 2. Make sure that the taxi has a yellow sticker on the windshield and rear paasenger side window that displays a 4 figure number. That is the only surefire way to ensure you are getting into a geniune registered taxi, and not a dangerous gypsy taxi. Gypsy taxis may have taxi painted on the side of the car, and even have the boarding on the roof, always look for the yellow stickers. If you ever find yourself to be lost, in general the easiest thing is to simply walk downhill. You will eventually find yourself on the Prado or another main avenue, then Youll be able to take a taxi to the downtown, if you are on the southside of the city Zona sur. 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